AMD EPYC 7543 's Advantages
Higher base frequency (2.8GHz vs 2GHz)
Larger L3 cache size (256MB vs 96MB)
Lower TDP (225W vs 250W)
Xeon 6746E 's Advantages
Released 3 years and 3 months late
Higher specification of memory (5600 vs 3200)
Newer PCIe version (5 vs 4)
More modern manufacturing process (5nm vs 7nm)