AMD EPYC 7643 's Advantages
Released 2 years and 3 months late
Higher specification of memory (3200 vs 4)
Larger L3 cache size (256MB vs 38.5MB)
More modern manufacturing process (7nm vs 14nm)
Xeon Platinum 8280 's Advantages
Higher base frequency (2.7GHz vs 2.3GHz)
Lower TDP (205W vs 225W)