AMD EPYC 9454 's Advantages
Released 15 years and 9 months late
Higher specification of memory (DDR5-4800 vs DDR2-667)
Newer PCIe version (5 vs 1)
More modern manufacturing process (5nm vs 90nm)
Opteron 8220 's Advantages
Higher base frequency (2.8GHz vs 2.75GHz)
Lower TDP (95W vs 290W)