AMD EPYC 9645 's Advantages
Released 17 years and 2 months late
Higher specification of memory (6000 vs 2)
Newer PCIe version (5 vs 1)
More modern manufacturing process (3nm vs 90nm)
Opteron 2222 's Advantages
Higher base frequency (3GHz vs 2.3GHz)
Lower TDP (95W vs 320W)