AMD EPYC 9645 's Advantages
Released 18 years and 2 months late
Higher specification of memory (6000 vs 667)
Newer PCIe version (5 vs 1)
More modern manufacturing process (3nm vs 90nm)
Opteron 8220 SE (F3) 's Advantages
Higher base frequency (2.8GHz vs 2.3GHz)
Lower TDP (120W vs 320W)