AMD EPYC 9754S 's Advantages
Released 10 years and 7 months late
Higher specification of memory (4800 vs 1866)
Newer PCIe version (5 vs 2)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)
Opteron 6376 's Advantages
Higher base frequency (2.3GHz vs 2.25GHz)
Lower TDP (115W vs 360W)