Intel Xeon E 2378 's Advantages
Released 14 years and 5 months late
Higher specification of memory (3200 vs 667)
Newer PCIe version (4 vs 1)
More modern manufacturing process (14nm vs 90nm)
Lower TDP (65W vs 120W)
Opteron 8222 SE 's Advantages
Higher base frequency (3GHz vs 2.6GHz)