Intel Xeon E3 1280 's Advantages
Higher base frequency (3.5GHz vs 2.6GHz)
Lower TDP (95W vs 205W)
Intel Xeon Platinum 8376HL 's Advantages
Released 10 years late
Higher specification of memory (DDR4-3200 vs DDR3)
Larger L3 cache size (38.5MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)