Intel Xeon E3 1280 's Advantages
Higher base frequency (3.5GHz vs 2GHz)
Lower TDP (95W vs 250W)
Xeon 6746E 's Advantages
Released 13 years and 2 months late
Higher specification of memory (5600 vs 3)
Newer PCIe version (5 vs 3)
Larger L3 cache size (96MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)