Intel Xeon E5 2643 's Advantages
Higher base frequency (3.3GHz vs 2.7GHz)
Lower TDP (130W vs 205W)
Xeon Platinum 8280M 's Advantages
Released 6 years and 9 months late
Higher specification of memory (2933 vs 3)
Larger L3 cache size (38.5MB vs 10MB)
More modern manufacturing process (14nm vs 32nm)