Intel Xeon E5 4640 's Advantages
Lower TDP (95W vs 205W)
Intel Xeon Platinum 8280M 's Advantages
Released 6 years and 7 months late
Higher specification of memory (DDR4-2933 vs DDR3)
Higher base frequency (2.7GHz vs 2.4GHz)
Larger L3 cache size (38.5MB vs 20MB)
More modern manufacturing process (14nm vs 32nm)