Intel Xeon E5645 's Advantages
Lower TDP (80W vs 205W)
Intel Xeon Platinum 8280 's Advantages
Released 8 years and 9 months late
Higher specification of memory (DDR4 vs DDR3)
Higher base frequency (2.7GHz vs 2.4GHz)
Larger L3 cache size (38.5MB vs 12MB)
More modern manufacturing process (14nm vs 32nm)