Intel Xeon E5649 's Advantages
Larger L3 cache size (12MB vs 8MB)
Intel Xeon E3 1280 v5 's Advantages
Released 4 years and 8 months late
Higher specification of memory (DDR4 vs DDR3)
Newer PCIe version (3 vs 2)
Higher base frequency (3.7GHz vs 2.533GHz)
More modern manufacturing process (14nm vs 32nm)