Intel Xeon Gold 6421N 's Advantages
Released 6 years and 11 months late
Higher specification of memory (DDR5-4400 vs DDR3)
Newer PCIe version (5 vs 3)
Larger L3 cache size (60MB vs 1.5MB)
More modern manufacturing process (10nm vs 14nm)
Intel Xeon D 1581 's Advantages
Lower TDP (65W vs 185W)