Opteron 1381 's Advantages
Lower TDP (115W vs 225W)
AMD EPYC 7453 's Advantages
Released 11 years and 9 months late
Higher specification of memory (3200 vs 1333)
Newer PCIe version (4 vs 2)
Higher base frequency (2.75GHz vs 2.5GHz)
Larger L3 cache size (64MB vs 6MB)
More modern manufacturing process (7nm vs 45nm)