Opteron 2220 SE (F2) 's Advantages
Higher base frequency (2.8GHz vs 2.25GHz)
Lower TDP (119W vs 500W)
AMD EPYC 9965 's Advantages
Released 18 years and 2 months late
Higher specification of memory (6000 vs 2)
Newer PCIe version (5 vs 1)
More modern manufacturing process (3nm vs 90nm)