Opteron 2220 SE (F3) 's Advantages
Higher base frequency (2.8GHz vs 2.2GHz)
Lower TDP (119W vs 155W)
AMD EPYC 7452 's Advantages
Released 13 years late
Higher specification of memory (3200 vs 2)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)