Opteron 2220 SE (F3) 's Advantages
Higher base frequency (2.8GHz vs 2.2GHz)
Lower TDP (119W vs 180W)
AMD EPYC 7601 's Advantages
Released 10 years and 10 months late
Higher specification of memory (2666 vs 2)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)