Opteron 2220 SE (F3) 's Advantages
Lower TDP (119W vs 280W)
AMD Ryzen Threadripper Pro 3945WX 's Advantages
Released 13 years and 11 months late
Higher specification of memory (3200 vs 2)
Newer PCIe version (4.0 vs 1)
Higher base frequency (4.0GHz vs 2.8GHz)
More modern manufacturing process (7nm vs 90nm)