Opteron 2222 's Advantages
Higher base frequency (3GHz vs 2.2GHz)
Lower TDP (95W vs 180W)
AMD EPYC 7601 's Advantages
Released 9 years and 10 months late
Higher specification of memory (DDR4-2666 vs DDR2)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)