Opteron 3380 's Advantages
Higher base frequency (2.6GHz vs 2.4GHz)
Lower TDP (65W vs 225W)
AMD EPYC 7642 's Advantages
Released 6 years and 8 months late
Higher specification of memory (3200 vs 3)
Newer PCIe version (4 vs 2)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)