Opteron 4386 's Advantages
Higher base frequency (3.1GHz vs 2.85GHz)
Lower TDP (95W vs 200W)
AMD EPYC 7443 's Advantages
Released 8 years and 3 months late
Higher specification of memory (DDR4-3200 vs DDR3)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)