Opteron 6180 SE 's Advantages
Lower TDP (140W vs 225W)
AMD EPYC 7543 's Advantages
Released 10 years and 1 months late
Higher specification of memory (DDR4-3200 vs DDR3-1333)
Newer PCIe version (4 vs 2)
Higher base frequency (2.8GHz vs 2.5GHz)
Larger L3 cache size (256MB vs 12MB)
More modern manufacturing process (7nm vs 45nm)