Opteron 6366 HE 's Advantages
Lower TDP (85W vs 120W)
AMD EPYC 7251 's Advantages
Released 4 years and 7 months late
Higher specification of memory (2400 vs 1866)
Newer PCIe version (3 vs 2)
Higher base frequency (2.1GHz vs 1.8GHz)
Larger L3 cache size (32MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)