Opteron 6376 's Advantages
Lower TDP (115W vs 130W)
AMD EPYC 7303 's Advantages
Released 10 years and 10 months late
Higher specification of memory (3200 vs 1866)
Newer PCIe version (4 vs 2)
Higher base frequency (2.4GHz vs 2.3GHz)
Larger L3 cache size (64MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)