Opteron 6376 's Advantages
Lower TDP (115W vs 155W)
AMD EPYC 7F52 's Advantages
Released 7 years and 5 months late
Higher specification of memory (DDR4-3200 vs DDR3)
Newer PCIe version (4 vs 2)
Higher base frequency (3.5GHz vs 2.3GHz)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)