Opteron 6376 's Advantages
Lower TDP (115W vs 225W)
AMD EPYC 7643P 's Advantages
Released 10 years and 10 months late
Higher specification of memory (3200 vs 1866)
Newer PCIe version (4 vs 2)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)