Opteron 6376 's Advantages
Lower TDP (115W vs 360W)
AMD EPYC 9554P 's Advantages
Released 10 years late
Higher specification of memory (4800 vs 1866)
Newer PCIe version (5 vs 2)
Higher base frequency (3.1GHz vs 2.3GHz)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (5nm vs 32nm)