Opteron 6378 's Advantages
Lower TDP (115W vs 165W)
Intel Xeon w3 2435 's Advantages
Released 10 years and 3 months late
Higher specification of memory (4400 vs 1866)
Newer PCIe version (5 vs 2)
Higher base frequency (3.1GHz vs 2.4GHz)
Larger L3 cache size (22.5MB vs 8MB)
More modern manufacturing process (10nm vs 32nm)