Opteron 6386 SE 's Advantages
Higher base frequency (2.8GHz vs 2.1GHz)
Lower TDP (140W vs 170W)
AMD EPYC 7281 's Advantages
Released 4 years and 7 months late
Higher specification of memory (DDR4-2666 vs DDR3)
Newer PCIe version (3 vs 2)
Larger L3 cache size (32MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)