Opteron 6386 SE 's Advantages
Lower TDP (140W vs 190W)
AMD EPYC 7343 's Advantages
Released 8 years and 4 months late
Higher specification of memory (3200 vs 1600)
Newer PCIe version (4 vs 2)
Higher base frequency (3.2GHz vs 2.8GHz)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)