Opteron 6386 SE 's Advantages
Higher base frequency (2.8GHz vs 2.5GHz)
Lower TDP (140W vs 180W)
AMD EPYC 7502 's Advantages
Released 6 years and 9 months late
Higher specification of memory (DDR4-3200 vs DDR3)
Newer PCIe version (4 vs 2)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)