Opteron 6386 SE 's Advantages
Higher base frequency (2.8GHz vs 2.3GHz)
Lower TDP (140W vs 320W)
AMD EPYC 9645 's Advantages
Released 11 years and 11 months late
Higher specification of memory (6000 vs 1600)
Newer PCIe version (5 vs 2)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (3nm vs 32nm)