Opteron 8212 HE (F2) 's Advantages
Lower TDP (68W vs 180W)
AMD EPYC 7451 's Advantages
Released 10 years and 10 months late
Higher specification of memory (DDR4-2666 vs DDR2-667)
Newer PCIe version (3 vs 1)
Higher base frequency (2.3GHz vs 2GHz)
More modern manufacturing process (14nm vs 90nm)