Opteron 8216 (F2) 's Advantages
Higher base frequency (2.4GHz vs 2.2GHz)
Lower TDP (95W vs 155W)
AMD EPYC 7452 's Advantages
Released 13 years late
Higher specification of memory (DDR4-3200 vs DDR2-667)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)