Opteron 8216 (F2) 's Advantages
Lower TDP (95W vs 280W)
AMD EPYC 9354 's Advantages
Released 16 years and 3 months late
Higher specification of memory (DDR5-4800 vs DDR2-667)
Newer PCIe version (5 vs 1)
Higher base frequency (3.25GHz vs 2.4GHz)
More modern manufacturing process (5nm vs 90nm)