Opteron 8216 HE (F3) 's Advantages
Lower TDP (68W vs 225W)
AMD EPYC 7543 's Advantages
Released 14 years and 7 months late
Higher specification of memory (DDR4-3200 vs DDR2-667)
Newer PCIe version (4 vs 1)
Higher base frequency (2.8GHz vs 2.4GHz)
More modern manufacturing process (7nm vs 90nm)