Opteron 8220 SE (F3) 's Advantages
Lower TDP (120W vs 240W)
AMD EPYC 7F72 's Advantages
Released 13 years and 8 months late
Higher specification of memory (3200 vs 667)
Newer PCIe version (4 vs 1)
Higher base frequency (3.2GHz vs 2.8GHz)
More modern manufacturing process (7nm vs 90nm)