Opteron 8220 's Advantages
Higher base frequency (2.8GHz vs 2.4GHz)
Lower TDP (95W vs 225W)
AMD EPYC 7642 's Advantages
Released 12 years and 6 months late
Higher specification of memory (3200 vs 667)
Newer PCIe version (4 vs 1)
More modern manufacturing process (7nm vs 90nm)