Opteron 8222 SE 's Advantages
Higher specification of memory (667 vs 3)
Higher base frequency (3GHz vs 2.4GHz)
Opteron 6278 's Advantages
Released 5 years and 1 months late
Newer PCIe version (2 vs 1)
More modern manufacturing process (32nm vs 90nm)
Lower TDP (115W vs 120W)