Opteron 8224 SE 's Advantages
Higher base frequency (3.2GHz vs 2.5GHz)
Lower TDP (120W vs 170W)
AMD EPYC 7261 's Advantages
Released 10 years and 10 months late
Higher specification of memory (DDR4-2666 vs DDR2-667)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)