Opteron 8224 SE 's Advantages
Higher base frequency (3.2GHz vs 2.1GHz)
Lower TDP (120W vs 170W)
AMD EPYC 7281 's Advantages
Released 9 years and 10 months late
Higher specification of memory (2666 vs 667)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)