AMD EPYC 7251 's Advantages
Released 10 years and 4 months late
Higher specification of memory (2400 vs 667)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)
Opteron 8220 's Advantages
Higher base frequency (2.8GHz vs 2.1GHz)
Lower TDP (95W vs 120W)