AMD EPYC 7281 's Advantages
Higher base frequency (2.1GHz vs 1.9GHz)
Lower TDP (170W vs 350W)
Intel Xeon w9 3495X 's Advantages
Released 5 years and 8 months late
Higher specification of memory (4800 vs 2666)
Newer PCIe version (5 vs 3)
Larger L3 cache size (105MB vs 32MB)
More modern manufacturing process (10nm vs 14nm)