AMD EPYC 7281 's Advantages
Released 4 years and 7 months late
Higher specification of memory (2666 vs 1600)
Newer PCIe version (3 vs 2)
Larger L3 cache size (32MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)
Opteron 6386 SE 's Advantages
Higher base frequency (2.8GHz vs 2.1GHz)
Lower TDP (140W vs 170W)