AMD EPYC 7281 's Advantages
Released 6 years and 4 months late
Higher specification of memory (2666 vs 1333)
Newer PCIe version (3 vs 2)
Larger L3 cache size (32MB vs 12MB)
More modern manufacturing process (14nm vs 32nm)
Xeon L5645 's Advantages
Higher base frequency (2.4GHz vs 2.1GHz)
Lower TDP (60W vs 170W)