AMD EPYC 7543 's Advantages
Released 11 years and 9 months late
Higher specification of memory (3200 vs 1333)
Newer PCIe version (4 vs 2)
Larger L3 cache size (256MB vs 6MB)
More modern manufacturing process (7nm vs 45nm)
Opteron 1389 's Advantages
Higher base frequency (2.9GHz vs 2.8GHz)
Lower TDP (115W vs 225W)