AMD EPYC 9645 's Advantages
Released 18 years and 2 months late
Higher specification of memory (6000 vs 2)
Newer PCIe version (5 vs 1)
More modern manufacturing process (3nm vs 90nm)
Opteron 2216 HE (F3) 's Advantages
Higher base frequency (2.4GHz vs 2.3GHz)
Lower TDP (68W vs 320W)