Intel Xeon D 1521 's Advantages
Lower TDP (45W vs 65W)
Intel Xeon E 2378 's Advantages
Released 5 years and 10 months late
Higher specification of memory (3200 vs 4)
Newer PCIe version (4 vs 3)
Higher base frequency (2.6GHz vs 2.4GHz)
Larger L3 cache size (16MB vs 1.5MB)