Intel Xeon E 2378 's Advantages
Released 14 years and 7 months late
Higher specification of memory (3200 vs 2)
Newer PCIe version (4 vs 1)
More modern manufacturing process (14nm vs 90nm)
Lower TDP (65W vs 95W)
Opteron 2220 's Advantages
Higher base frequency (2.8GHz vs 2.6GHz)